GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs4663866 | 1 | rs4663865 | chr2:239145960 | LOC151174 | chr2:239133754-239140318:- | -0.43 | -4.52 | 8.07E-6 | Irritable bowel syndrome |
| BLCA | cis | rs4372836 | 1 | rs4666118 | chr2:28951698 | TRMT61B | chr2:29072690-29093175:- | -0.28 | -4.83 | 1.97E-6 | Body mass index |
| BLCA | cis | rs4372836 | 1 | rs4666119 | chr2:28975690 | TRMT61B | chr2:29072690-29093175:- | -0.31 | -5.39 | 1.26E-7 | Body mass index |
| BLCA | cis | rs2243480 | 1 | rs466983 | chr7:65520496 | CCT6P1 | chr7:65216092-65228661:+ | 0.3 | 4.19 | 3.43E-5 | Diabetic kidney disease |
| BLCA | cis | rs7611238 | 1 | rs4677834 | chr3:195093631 | C3orf21 | chr3:194789015-194991895:- | -0.28 | -5.42 | 1.07E-7 | Body mass index |
| BLCA | cis | rs30187 | 1 | rs469758 | chr5:96121715 | ERAP1 | chr5:96096515-96149837:- | -0.51 | -10.95 | 1.77E-24 | Ankylosing spondylitis |
| BLCA | cis | rs30187 | 1 | rs469758 | chr5:96121715 | ERAP2 | chr5:96211644-96255398:+ | 0.33 | 5.45 | 9.1E-8 | Ankylosing spondylitis |
| BLCA | cis | rs4699052 | 1 | rs4699052 | chr4:104137790 | MANBA | chr4:103552644-103682151:- | 0.26 | 4.15 | 4.05E-5 | Testicular germ cell tumor |
| BLCA | cis | rs4699052 | 1 | rs4699055 | chr4:104154500 | MANBA | chr4:103552644-103682151:- | 0.26 | 4.26 | 2.61E-5 | Testicular germ cell tumor |
| BLCA | cis | rs1577917 | 1 | rs4706254 | chr6:86602813 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -10.33 | 3.26E-22 | Response to antipsychotic treatment |
| BLCA | cis | rs1577917 | 1 | rs4707239 | chr6:86610717 | SNHG5 | chr6:86386726-86388451:- | -0.55 | -10 | 4.56E-21 | Response to antipsychotic treatment |
| BLCA | cis | rs9457247 | 1 | rs4710147 | chr6:167374239 | RNASET2 | chr6:167343008-167412795:- | 0.22 | 4.7 | 3.57E-6 | Crohn's disease |
| BLCA | cis | rs1474698 | 1 | rs4712120 | chr6:56092916 | COL21A1 | chr6:55921389-56258892:- | 0.33 | 5.88 | 8.79E-9 | Pulse pressure |
| BLCA | cis | rs9473555 | 1 | rs4715129 | chr6:49415043 | CENPQ | chr6:49431096-49460820:+ | -0.28 | -5.82 | 1.22E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs4715129 | chr6:49415043 | MUT | chr6:49398994-49431031:- | 0.27 | 5.44 | 9.37E-8 | Folate pathway vitamin levels |